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Strain
C57BL/6-Tgfbr3tm1.1Jba/+

Summary Data Summary
Official Name C57BL/6-Tgfbr3tm1.1Jba/+
Common Name C57BL/6-Tgfbr3-/+
Description transforming growth factor, beta receptor III heterozygote
knockout on a B6 background

Exon 3 of this locus encodes the N terminus, including a
portion of the extracellular ligand binding domain. A floxed
neo-cassette was placed upstream of exon 3 and a single loxP
site was placed downstream of exon 3. Mice carrying the
targeted mutation in the germline were crossed with
cre-transgenic mice to remove exon 3 and the neo-cassette,
leaving in its place a single loxP site. Ligand crosslinking
with 125I-TGFbeta to embryonic fibroblasts isolated from
homozygotes confirms loss of protein expression.
Development Status Phenotyping ongoing
Creation Method knockout
Background C57BL/6J
Breeding Type intercross
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 1


Investigators
NameInstitution
Joey BarnettVanderbilt University


Genomic Information
GeneAllele 1Allele 2Protocol
Tgfbr3knockoutwildNot Specified


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