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Strain
B6.129-Insrtm1Khn Igf1tm1Dlr Tg(Fabp4-cre)#Abel

Summary Data Summary
Official Name B6.129-Insrtm1Khn Igf1tm1Dlr Tg(Fabp4-cre)#Abel
Common Name B6.129-Insrlox/lox Igf1lox/lox Tg(aP2-cre)
Description Adipocyte specific double knockout on a mixed B6 and 129/Sv
background. The Insr (insulin receptor) and Igf1 (insulin
like growth factor 1) genes were floxed and knocked out. The
adiopcyte specific promoter Fbp4 (aP2) drives the expression
of Cre recombinase.
Development Status Phenotyping ongoing
Creation Method knockout
Breeding Type intercross
TypeCount
Investigators 1
Genomics - Modifications 2
Genomics - Transgenes 1
Experiments 1
Publications 1


Investigators
NameInstitution
Jeremie BoucherHarvard Medical School


Genomic Information
GeneAllele 1Allele 2Protocol
Insrknockin (lox)knockin (lox)Not Specified
Igf1knockin (lox)knockin (lox)Not Specified
EnhancerPromoterGeneCopies
Not SpecifiedFabp4CRENot Specified






PublicationAltmetricsSubmitted ByPubMed IDStatus
Impaired thermogenesis and adipose tissue development in mice with fat-specific disruption of insulin and IGF-1 signalling.
Boucher J, Mori MA, Lee KY, Smyth G, Liew CW, Macotela Y, Rourk M, Bluher M, Russell SJ, Kahn CR
Nature communications, 2012 (3), 902
22692545
Published

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