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Publication
Impaired thermogenesis and adipose tissue development in mice with fat-specific
disruption of insulin and IGF-1 signalling.
Authors Boucher J, Mori MA, Lee KY, Smyth G, Liew CW, Macotela Y, Rourk M, Bluher M,
Russell SJ, Kahn CR
Submitted By Jeremie Boucher on 9/18/2012
Status Published
Journal Nature communications
Year 2012
Date Published 1/1/2011
Volume : Pages 3 : 902
PubMed Reference 22692545
Abstract Insulin and insulin-like growth factor 1 (IGF-1) have important roles in
adipocyte differentiation, glucose tolerance and insulin sensitivity. Here to
assess how these pathways can compensate for each other, we created mice with a
double tissue-specific knockout of insulin and IGF-1 receptors to eliminate all
insulin/IGF-1 signalling in fat. These FIGIRKO mice had markedly decreased white
and brown fat mass and were completely resistant to high fat diet-induced
obesity and age- and high fat diet-induced glucose intolerance. Energy
expenditure was increased in FIGIRKO mice despite a >85% reduction in brown fat
mass. However, FIGIRKO mice were unable to maintain body temperature when placed
at 4?°C. Brown fat activity was markedly decreased in FIGIRKO mice but was
responsive to ß3-receptor stimulation. Thus, insulin/IGF-1 signalling has a
crucial role in the control of brown and white fat development, and, when
disrupted, leads to defective thermogenesis and a paradoxical increase in basal
metabolic rate.








Genes
SymbolDescription
Fabp4fatty acid binding protein 4, adipocyte
Igf1insulin-like growth factor 1
Insrinsulin receptor

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