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C56BL/6J mice with homozygous knockout of Plasminogen and
heterozygous KO/Wildtype for the Fibrinogen alpha gene.
Plg KO: A PGK-HPRT minigene replaces proximal promoter
sequences and the first two exons of the Plg gene. Northern
analysis and enzymatic activity assays were used to
demonstrate the lack of a transcript and functional protein,
respectively, in homozygous mutant animals.
Fga KO: An HPRT minigene cassette was inserted into exon 1
in sequences corresponding to the the signal peptide
sequence of the Fga gene. Transcripts from this allele were
not detected in total liver RNA derived from homozygous mice
and an in vitro clotting assay demonstrated that no
functional fibrinogen protein was present in plasma derived
from homozygous mice.
Genomics - Modifications
Curation Flag Information
New comment to be added:
Oxymax Order #2577 6/28/12
Fibrinolysis is essential for fracture repair and prevention of heterotopic ossification.
Yuasa M, Mignemi NA, Nyman JS, Duvall CL, Schwartz HS, Okawa A, Yoshii T, Bhattacharjee G, Zhao C, Bible JE, Obremskey WT, Flick MJ, Degen JL, Barnett JV, Cates JM, Schoenecker JG
The Journal of clinical investigation
, 2015 (125), 3117 - 31
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Financial support for this work was provided by the NIDDK Mouse Metabolic Phenotyping Centers (National MMPC, RRID:SCR_008997,
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