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Strain
B6.129S4-Pparatm1Gonz

Summary Data Summary
Official Name B6.129S4-Pparatm1Gonz
Common Name B6;129S4-Pparatm1Gonz
Description Mice homozygous for the targeted mutation are viable and
fertile. An altered response to a group of compounds
(peroxisome proliferators) that induce peroxisome
proliferation and hepatocarcinogenesis is observed. No
peroxisome proliferation response is detected when these
mice are challenged with classical peroxisome proliferators.
Typically, such a response includes hepatomegaly, peroxisome
proliferation and transcriptional activation of a set of
target enzyme genes. Accumulation of lipid droplets observed
in liver tissue suggests that Ppara is involved in
maintaining the homeostasis of hepatic lipid metabolism.
Homozygotes exhibit increased gonadal adipose tissue stores,
abnormal epidermal development and delayed wound healing.
This mutant mouse strain may be useful in studies of lipid
metabolism, cell proliferation, diabetes, obesity, and wound
healing.
Development Status Phenotyping ongoing
Creation Method knockout
Background C57BL/6J
Breeding Generations 8
Phenotype Description increased gonadal fat pad weight; abnormal circulating
glucose level, abnormal circulating insulin level, increased
circulating triglyceride level; hepatic steatosis
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 3


Investigators
NameInstitution
Owen McGuinnessVanderbilt University


Genomic Information
GeneAllele 1Allele 2Protocol
PparaknockoutknockoutNot Specified


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