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Strain
C57BL/6-Rag1tm1Mom Tg(Acta2-Cyba)

Summary Data Summary
Official Name C57BL/6-Rag1tm1Mom Tg(Acta2-Cyba)
Common Name C57BL/6-Rag1tm1Mom Tg(SMP8-p22phox)
Description p22phox was cloned downstream of the smooth muscle a-actin
promoter fragment SMP-8 and upstream of a SV40 poly A
fragment. These animals are also homozygous Rag1 knockout.

Rag1 KO: A 1356 bp genomic fragment of the Rag1 gene,
encoding the nuclear localization signal and the zinc-finger
motif, was replaced by a neomycin cassette. A mutant
transcript expressed from this allele was detected by
Northern blot in bone marrow derived cell lines from
homozygous mice.
Development Status Phenotyping ongoing
Creation Method knockout
Breeding Type intercross
TypeCount
Investigators 1
Genomics - Modifications 1
Genomics - Transgenes 1
Experiments 1


Investigators
NameInstitution
David HarrisonVanderbilt University


Genomic Information
GeneAllele 1Allele 2Protocol
Rag1knockoutknockoutNot Specified
EnhancerPromoterGeneCopies
Not SpecifiedActa2CybaNot Specified


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