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Strain
C57BL/6-Tg(Ckm-Klf15)

Summary Data Summary
Official Name C57BL/6-Tg(Ckm-Klf15)
Common Name C57BL/6-Tg(Ckm-Klf15)
Description Mice where created by inserting a transgene containing
Kruppel-like factor 15 with the muscle creatine kinase. The
Klf15 gene is overexpressed in muscle tissue.
Development Status Phenotyping ongoing
Creation Method transgenic
Background C57BL/6
Breeding Type intercross
Phenotype Description These transgenic mice constituitively over express the
transcription factor KLF15 in a skeletal muscle specific
fashion using the MCK promoter at 4-5 fold over control. The
Tg mice have normal muscle mass. They have substantially
increased capacity for forced endurance exercise on a rodent
treadmill compared to littermate nontransgenic controls (No
incline, constant running speed at approx 12-14 m/min,
representing ~70% VO2 max).
TypeCount
Investigators 1
Genomics - Transgenes 1
Experiments 1
Publications 1


Investigators
NameInstitution
Saptarsi HaldarAmgen


Genomic Information
EnhancerPromoterGeneCopies
Not SpecifiedCkmKlf15Not Specified






PublicationAltmetricsSubmitted ByPubMed IDStatus
Glucocorticoids enhance muscle endurance and ameliorate Duchenne muscular dystrophy through a defined metabolic program.
Morrison-Nozik A, Anand P, Zhu H, Duan Q, Sabeh M, Prosdocimo DA, Lemieux ME, Nordsborg N, Russell AP, MacRae CA, Gerber AN, Jain MK, Haldar SM
Proceedings of the National Academy of Sciences of the United States of America, 2015 (112), E6780 - 9
Submitted Externally
26598680
Published

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