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Strain
C57BL/6-Tg(Ckm-Klf15)

Summary Data Summary
Official Name C57BL/6-Tg(Ckm-Klf15)
Common Name C57BL/6-Tg(Ckm-Klf15)
Description Mice where created by inserting a transgene containing
Kruppel-like factor 15 with the muscle creatine kinase. The
Klf15 gene is overexpressed in muscle tissue.
Development Status Phenotyping ongoing
Creation Method transgenic
Background C57BL/6
Breeding Type intercross
Phenotype Description These transgenic mice constituitively over express the
transcription factor KLF15 in a skeletal muscle specific
fashion using the MCK promoter at 4-5 fold over control. The
Tg mice have normal muscle mass. They have substantially
increased capacity for forced endurance exercise on a rodent
treadmill compared to littermate nontransgenic controls (No
incline, constant running speed at approx 12-14 m/min,
representing ~70% VO2 max).
TypeCount
Investigators 1
Genomics - Transgenes 1
Experiments 1
Publications 1


Investigators
NameInstitution
Saptarsi HaldarAmgen


Genomic Information
EnhancerPromoterGeneCopies
Not SpecifiedCkmKlf15Not Specified


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