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Strain
B6.129-Akap5tm1Gsm

Summary Data Summary
Official Name B6.129-Akap5tm1Gsm
Common Name D36
Description A stop codon (TAG) replaced the codon for Leu710 (TTA)
(L710X), truncating the last 36 residues that are important
for binding to protein kinase A (PKA). A loxP-flanked
neomycin resistance cassette was also inserted downstream of
the lone coding exon. After germ line transmission, the
neomycin resistance cassette was removed by crossing with
cre-transgenic (ROSA26) mice. Western blots for PKA subunits
from postsynaptic densities of the forebrain indicated
reduced levels of protein, confirming mutation of the
targeted gene.
Development Status Phenotyping ongoing
Creation Method knockout
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 1


Investigators
NameInstitution
Johannes HellUniversity of California Davis


Genomic Information
GeneAllele 1Allele 2Protocol
Akap5nucleotide subsitutionnucleotide subsitutionNot Specified


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