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Strain
B6.129P2-Lyz2tm1(cre)Ifo/J

Summary Data Summary
Official Name B6.129P2-Lyz2tm1(cre)Ifo/J
Common Name B6.129P2-Lyz2tm1(cre)Ifo/J
Description The LysMcre knock-in allele has a nuclear-localized Cre
recombinase inserted into the first coding ATG of the
lysozyme 2 gene (Lyz2); both abolishing endogenous Lyz2 gene
function and placing NLS-Cre expression under the control of
the endogenous Lyz2 promoter/enhancer elements. When crossed
with a strain containing loxP site flanked sequence of
interest, Cre-mediated recombination results in deletion of
the targeted gene in the myeloid cell lineage, including
monocytes, mature macrophages, and granulocytes.
Development Status Phenotyping ongoing
Creation Method knockin
Phenotype Description Mice that are homozygous for the targeted mutation are
viable, fertile, normal in size and do not display any gross
physical or behavioral abnormalities. This strain represents
an effective tool for generating myeloid cell-specific
targeted mutants.
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 1


Investigators
NameInstitution
Willa HsuehOhio State University-Main Campus


Genomic Information
GeneAllele 1Allele 2Protocol
Lyz2knockin (Cre)knockin (Cre)Not Specified


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