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Global knockout of tripartite motif-containing 63, Trim63.
An in-frame lacZ gene and neomycin selection cassette
replaced approximately 8 kb of gene sequences, including
exons 1-4 and most of exon 5. Northern blot analysis on RNA
derived from muscle of homozygous mice confirmed that no
wild-type transcript is expressed from this allele.
Beta-glalctosidase is expressed from this allele under the
control of the endogenous promoter. A targeted homozygous
mutation in this gene results in resistance to skeletal
muscle atrophy in response to nerve injury.
cardiac hypertrophy, heart left ventricle hypertrophy
Genomics - Modifications
University of Iowa
Curation Flag Information
New comment to be added:
Lipid droplet and mitochondrial analysis in aged MURF/1 KO Mice
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Financial support for this work was provided by the NIDDK Mouse Metabolic Phenotyping Centers (National MMPC, RRID:SCR_008997,
) under the MICROMouse Program, grants DK076169.
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