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Strain
B6;129S1-Trim63tm1Glas

Summary Data Summary
Official Name B6;129S1-Trim63tm1Glas
Common Name B6;129S1-Trim63-/-
Description Global knockout of tripartite motif-containing 63, Trim63.
An in-frame lacZ gene and neomycin selection cassette
replaced approximately 8 kb of gene sequences, including
exons 1-4 and most of exon 5. Northern blot analysis on RNA
derived from muscle of homozygous mice confirmed that no
wild-type transcript is expressed from this allele.
Beta-glalctosidase is expressed from this allele under the
control of the endogenous promoter. A targeted homozygous
mutation in this gene results in resistance to skeletal
muscle atrophy in response to nerve injury.
Development Status Phenotyping ongoing
Creation Method knockout
Phenotype Description cardiac hypertrophy, heart left ventricle hypertrophy
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 1


Investigators
NameInstitution
Sue BodineUniversity of Iowa


Genomic Information
GeneAllele 1Allele 2Protocol
Trim63knockoutknockoutNot Specified


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