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These ILKfl/fl mice possess loxP sites flanking exons 5-12
of the integrin linked kinase (Ilk) gene. ILK is a
transmembrane serine/threonine protein kinase involved in
gene expression, cell proliferation, migration, adhesion,
and survival. Mice that are homozygous for this allele are
viable and fertile. When these mutant mice are bred to mice
that express Cre recombinase, resulting offspring will have
exons 5-12 deleted in cre-expressing tissues.
For example, when crossed to B6.Cg-Tg(ACTA1-cre)79Jme/J mice
(Stock No. 006149), expressing Cre recombinase in striated
muscle, this mutant mouse strain develops widespread
progressive muscular dystrophy.
When crossed to STOCK Tg(KRT14-cre)1Amc/J mice (Stock No.
004782), expressing Cre recombinase in skin, this mutant
mouse strain dies perinatally and exhibits skin blistering
and severe defects in hair follicle morphogenesis.
When crossed to B6.Cg-Tg(NPHS2-cre)295Lbh/J mice (Stock No.
008205), expressing Cre recombinase in kidney podocytes,
this mutant mouse strain develops albuminuria,
glomerulosclerosis, and kidney failure, leading to death
beginning at 10 wk of age.
When crossed to B6;SJL-Tg(Krt1-15-cre/PGR)22Cot/J mice
(Stock No. 005249), expressing RU-486 induced Cre
recombinase in epithelial and hair follicle stem cells, this
mutant mouse strain exhibits impaired cutaneous wound
healing and decreased wound closure rates.
Genomics - Modifications
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New comment to be added:
Sable Energy Balance #21850 8/17/15
Sable Energy Balance #21850 8/21/17
Sable Energy Balance #21857 9/21/15
Sable Energy Balance #22172 2/20/17
Sable Energy Balance #22172 5/31/17
Sable Energy Balance 11/17/14 #18465
Integrin-Linked Kinase Is Necessary for the Development of Diet-Induced Hepatic Insulin Resistance.
Williams AS, Trefts E, Lantier L, Grueter CA, Bracy DP, James FD, Pozzi A, Zent R, Wasserman DH
, 2017 (66), 325 - 334
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Financial support for this work was provided by the NIDDK Mouse Metabolic Phenotyping Centers (National MMPC, RRID:SCR_008997,
) under the MICROMouse Program, grants DK076169.
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