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Strain
B6;129-Ilktm1Star Tg(ACTA1-cre)79Jme

Summary Data Summary
Official Name B6;129-Ilktm1Star Tg(ACTA1-cre)79Jme
Common Name Ilktm1Star Tg(ACTA1-cre)79Jme
Description These ILKfl/fl mice possess loxP sites flanking exons 5-12
of the integrin linked kinase (Ilk) gene. ILK is a
transmembrane serine/threonine protein kinase involved in
gene expression, cell proliferation, migration, adhesion,
and survival. Mice that are homozygous for this allele are
viable and fertile. When these mutant mice are bred to mice
that express Cre recombinase, resulting offspring will have
exons 5-12 deleted in cre-expressing tissues.

For example this strain was crossed to
B6.Cg-Tg(ACTA1-cre)79Jme/J mice (Stock No. 006149),
expressing Cre recombinase in striated muscle, this mutant
mouse strain develops widespread progressive muscular
dystrophy.
Development Status Phenotyping ongoing
Creation Method knockout
Breeding Type intercross
TypeCount
Investigators 1
Genomics - Modifications 1
Genomics - Transgenes 1
Experiments 6
Publications 1


Investigators
NameInstitution
David WassermanVanderbilt University


Genomic Information
GeneAllele 1Allele 2Protocol
Ilkknockin (lox)knockin (lox)Not Specified
EnhancerPromoterGeneCopies
Not SpecifiedACTA1CRENot Specified


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