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These ILKfl/fl mice possess loxP sites flanking exons 5-12
of the integrin linked kinase (Ilk) gene. ILK is a
transmembrane serine/threonine protein kinase involved in
gene expression, cell proliferation, migration, adhesion,
and survival. Mice that are homozygous for this allele are
viable and fertile. When these mutant mice are bred to mice
that express Cre recombinase, resulting offspring will have
exons 5-12 deleted in cre-expressing tissues.
For example this strain was crossed to
B6.Cg-Tg(ACTA1-cre)79Jme/J mice (Stock No. 006149),
expressing Cre recombinase in striated muscle, this mutant
mouse strain develops widespread progressive muscular
Genomics - Modifications
Genomics - Transgenes
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New comment to be added:
Sable Energy Balance #21850 8/17/15
Sable Energy Balance #21850 8/21/17
Sable Energy Balance #21857 9/21/15
Sable Energy Balance #22172 2/20/17
Sable Energy Balance #22172 5/31/17
Sable Energy Balance 11/17/14 #18465
Integrin-Linked Kinase in Muscle Is Necessary for the Development of Insulin Resistance in Diet-Induced Obese Mice.
Kang L, Mokshagundam S, Reuter B, Lark DS, Sneddon CC, Hennayake C, Williams AS, Bracy DP, James FD, Pozzi A, Zent R, Wasserman DH
, 2016 (65), 1590 - 600
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Financial support for this work was provided by the NIDDK Mouse Metabolic Phenotyping Centers (National MMPC, RRID:SCR_008997,
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