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Strain
B6.C3-Tg(Mt1-CBS*I278T)1Waku

Summary Data Summary
Official Name B6.C3-Tg(Mt1-CBS*I278T)1Waku
Common Name Tg-I278T
Description The mouse promoter was used to drive zinc-inducible
expression of the human cDNA with a point mutation that
results in the amino acid substitution of threonine for
isoleucine at position 278. This mutation was identified in
patients with CBS deficiency. Three lines were created with
no line numbers given.

mouse model of homocystinuria, an inherited metabolic
disorder resulting from
the lack of cystathionine beta-synthase (CBS) activity
Development Status Not specified/Other
Creation Method transgenic
TypeCount
Investigators 1
Genomics - Transgenes 1
Experiments 3


Investigators
NameInstitution
Tomas MajtanUniversity of Colorado at Denver and Health Sciences Center


Genomic Information
EnhancerPromoterGeneCopies
Not SpecifiedMt1CbsNot Specified


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