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Strain
B6;129X1-Gprc6atm1Ldq

Summary Data Summary
Official Name B6;129X1-Gprc6atm1Ldq
Common Name C57BL/6-Gprc6atm1Ldq
Description A floxed PGK-hygromycin cassette replaced exon 2. Absence of
transcription was demonstrated by RT-PCR and Western blot
analysis confirmed the absence of protein.
Development Status Phenotyping ongoing
Creation Method knockout
Background 129X1/SvJ
Breeding Type intercross
Phenotype Description decreased circulating testosterone level, increased
circulating estradiol level (males), decreased circulating
insulin level; increased circulating glucose level, abnormal
glucose tolerance, increased insulin sensitivity; increased
liver triglyceride level; increased urine calcium level,
increased urine phosphate level, increased urine
beta2-microglobulin level; hepatic steatosis; decreased lean
body mass; increased white adipose tissue amount; decreased
bone mineral density, abnormal bone mineralization; abnormal
mammary gland development (males), decreased seminary
vesicle weight, small testis
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 1


Investigators
NameInstitution
Min PiUniversity of Tennessee Health Science Center College of Med


Genomic Information
GeneAllele 1Allele 2Protocol
Gprc6aknockoutknockoutNot Specified


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