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Strain
C57BL/6-Sort1tm1Xen

Summary Data Summary
Official Name C57BL/6-Sort1tm1Xen
Common Name Sort1 KO
Description Whole body knockout of Sort1 gene on B6 background.

The Sort1 gene (accession number: NM_019972) was silenced by
inserting a stop codon into the second intron of the Sort1
gene through gene trapping technology.
Development Status Phenotyping ongoing
Creation Method knockout
Background C57BL/6J
Breeding Type backcross
Breeding Generations 7
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 1
Publications 2


Investigators
NameInstitution
Tiangang LiUniversity of Oklahoma Health Sciences Center


Genomic Information
GeneAllele 1Allele 2Protocol
Sort1knockoutknockoutNot Specified






PublicationAltmetricsSubmitted ByPubMed IDStatus
Sortilin 1 Modulates Hepatic Cholesterol Lipotoxicity in Mice via Functional Interaction with Liver Carboxylesterase 1.
Li J, Wang Y, Matye DJ, Chavan H, Krishnamurthy P, Li F, Li T
The Journal of biological chemistry, 2017 (292), 146 - 160
Submitted Externally
27881673
Published
Sortilin 1 knockout alters basal adipose glucose metabolism but not diet-induced obesity in mice.
Li J, Matye DJ, Wang Y, Li T
FEBS letters, 2017 (591), 1018 - 1028
Submitted Externally
28236654
Published

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