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Strain
B6.129X1-Pnpla8tm1Rigr

Summary Data Summary
Official Name B6.129X1-Pnpla8tm1Rigr
Common Name C57BL/6-Pnpla8tm1Rigr
Description Exon 5 was replaced with a neo cassette. This exon is
critical to the catalytic domain of the protein product. The
absence of the modified transcript was confirmed by northern
blot analysis of extracts from the heart, liver, skeletal,
and kidney tissue.
Development Status Phenotyping ongoing
Creation Method knockout
Background C57BL/6
Breeding Type intercross
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 1
Publications 1


Investigators
NameInstitution
Richard GrossWashington University in St Louis


Genomic Information
GeneAllele 1Allele 2Protocol
Pnpla8knockoutknockoutNot Specified






PublicationAltmetricsSubmitted ByPubMed IDStatus
Genetic ablation of calcium-independent phospholipase A2gamma leads to alterations in mitochondrial lipid metabolism and function resulting in a deficient mitochondrial bioenergetic phenotype.
Mancuso DJ, Sims HF, Han X, Jenkins CM, Guan SP, Yang K, Moon SH, Pietka T, Abumrad NA, Schlesinger PH, Gross RW
The Journal of biological chemistry, 2007 (282), 34611 - 22
Submitted Externally
17923475
Published

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