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Strain
B6.129-Ank2tm2Bnt

Summary Data Summary
Official Name B6.129-Ank2tm2Bnt
Common Name Ank2L1622I
Description An L1622I (CTG to ATC) mutation in exon 19 and loxP-flanked
neomycin cassette were knocked into the gene. In humans, the
mutation is involved with the setting of hereditary cardiac
arrhythmia. Cre-mediated recombination removed the selection
cassette. Western blot analysis confirmed reduced protein
expression in the fat, liver, skeletal muscle, pancreatic
beta cells, mouse embryonic fibroblasts and heart but not
the brain.
Development Status Phenotyping ongoing
Creation Method knockin
Background C57BL/6J
Breeding Type intercross
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 4
Publications 1


Investigators
NameInstitution
Vann BennettDuke University Medical Center


Genomic Information
GeneAllele 1Allele 2Protocol
Ank2nucleotide insertionnucleotide insertionNot Specified






PublicationAltmetricsSubmitted ByPubMed IDStatus
Ankyrin-B metabolic syndrome combines age-dependent adiposity with pancreatic ß cell insufficiency.
Lorenzo DN, Healy JA, Hostettler J, Davis J, Yang J, Wang C, Hohmeier HE, Zhang M, Bennett V
The Journal of clinical investigation, 2015 (125), 3087 - 102
Submitted Externally
26168218
Published

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