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Strain
B6.129X1-Faahtm1Crv

Summary Data Summary
Official Name B6.129X1-Faahtm1Crv
Common Name C57BL/6-Faahtm1Crv
Description Exon 1 and approximately 2kb of upstream sequence were
replaced by a PGK-neo selection cassette. Western blot
analysis of brain and liver protein extracts and
immunofluorescence analysis of cerebral sections showed an
absence of encoded protein in homozygous mutant mice. Assays
using labeled substrate showed significant reductions
(50-100 fold) of hydrolytic activity in homozygous mutant
mice.
Development Status Phenotyping ongoing
Creation Method knockout
Background C57BL/6
Breeding Type intercross
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 2
Publications 1


Investigators
NameInstitution
Gerald I. ShulmanYale University


Genomic Information
GeneAllele 1Allele 2Protocol
FaahknockoutknockoutNot Specified






PublicationAltmetricsSubmitted ByPubMed IDStatus
Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism.
Brown WH, Gillum MP, Lee HY, Camporez JP, Zhang XM, Jeong JK, Alves TC, Erion DM, Guigni BA, Kahn M, Samuel VT, Cravatt BF, Diano S, Shulman GI
Proceedings of the National Academy of Sciences of the United States of America, 2012 (109), 14966 - 71
Submitted Externally
22912404
Published

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