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Strain
C57BL/6-Nr0b2tm1Ykl Tg(Alb-cre)21Mgn

Summary Data Summary
Official Name C57BL/6-Nr0b2tm1Ykl Tg(Alb-cre)21Mgn
Common Name C57BL/6-Nr0b2lox/lox Tg(Alb-cre)21Mgn
Description This strain is a liver specific knockout of the Nr0b2 gene
(SHP). A transgenic construct containing a 2.34 kbp mouse
albumin enhancer/promoter, nuclear localization
sequence-modified Cre recombinase and a 2.1 kbp fragment
from the human growth hormone gene was injected into
B6D2(F2) pronuclei. These mice were subsequently backcrossed
to C57BL/6J mice. A targeting construct containing loxP
sites were inserted into the Nr0b2 (SHP) gene and were
created in the lab of Dr. Yoon Kwang Lee at Northeast Ohio
Medical University, Rootstown, OH .
Development Status Phenotyping ongoing
Breeding Type intercross
TypeCount
Investigators 1
Genomics - Modifications 1
Genomics - Transgenes 1
Experiments 1


Investigators
NameInstitution
John StaffordVanderbilt University


Genomic Information
GeneAllele 1Allele 2Protocol
Nr0b2knockin (lox)knockin (lox)Not Specified
EnhancerPromoterGeneCopies
Not SpecifiedAlbCRENot Specified


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