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Strain
B6.Cg-Cav1tm1Mls/J

Summary Data Summary
Official Name B6.Cg-Cav1tm1Mls/J
Common Name C57BL/6-Cav1-/-/J
Description The original Jax strain used targeting vector containing a
neomycin resistance gene to disrupt 2.2 Kb of sequence
containing exons 1 and 2. The construct was electroporated
into WW6 embryonic stem (ES) cells (75% 129/Sv, 20%
C57BL/6J, 5% SJL). Correctly targeted ES cells were injected
into C57BL/6 blastocysts. The resulting chimeric animals
were crossed to C57BL/6J mice for approximately 10
generations. The laboratory then crossed these mice to a
Jackson Laboratory Albino strain and after subsequent
crosses breed out the Albino mutation. All pups breed with
black coat color.
Development Status Phenotyping ongoing
Creation Method knockout
Breeding Type intercross
Phenotype Description Mice that are homozygous for this caveolin, caveolae protein
1 (Cav1) knock-out exhibit exercise intolerance when
challenged, resistant to diet-induced obesity and are
slightly hyperphagic. This mutant mouse strain may be useful
in studies of vesicular and cholesterol trafficking, signal
transduction and tumorigenesis.
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 1


Investigators
NameInstitution
Anna HemnesVanderbilt University


Genomic Information
GeneAllele 1Allele 2Protocol
Cav1knockoutknockoutNot Specified


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