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Strain
B6.129-Gys2tm1.1Pro Tg(Alb-cre)21Mgn

Summary Data Summary
Official Name B6.129-Gys2tm1.1Pro Tg(Alb-cre)21Mgn
Common Name LGS KO
Description Gys2 fl/fl: A loxP site was inserted upstream of exon 5, and
a floxed neo cassette was inserted downstream of exon 6. Cre
mediated recombination removes the neo cassette leaving
exons 5 and 6 floxed.

Alb-cre: The transgene contains a 2.34 kb mouse albumin
enhancer/promoter (M. Magnuson verified mouse promoter,
personal communication), a nuclear localization
sequence-modified Cre recombinase gene and a 2.1 kb fragment
from the human growth hormone gene. The promoter is active
in hepatocyte cells of the liver. 7 copies of the transgene
are estimated to be present.
Development Status Phenotyping ongoing
Creation Method knockout
Breeding Type intercross
TypeCount
Investigators 1
Genomics - Modifications 1
Genomics - Transgenes 1
Experiments 1
Publications 1


Investigators
NameInstitution
Peter RoachIndiana University-Purdue University-Indianapolis


Genomic Information
GeneAllele 1Allele 2Protocol
Gys2knockoutknockoutNot Specified
EnhancerPromoterGeneCopies
Not SpecifiedAlbCRENot Specified






PublicationAltmetricsSubmitted ByPubMed IDStatus
Impaired glucose tolerance and predisposition to the fasted state in liver glycogen synthase knock-out mice.
Irimia JM, Meyer CM, Peper CL, Zhai L, Bock CB, Previs SF, McGuinness OP, DePaoli-Roach A, Roach PJ
The Journal of biological chemistry, 2010 (285), 12851 - 12861
20178984
Published

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