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Strain
FVB-Tg(NPHS2-rtTA2*M2)1Jbk Tg(tetO-Vegfa)90Ala

Summary Data Summary
Official Name FVB-Tg(NPHS2-rtTA2*M2)1Jbk Tg(tetO-Vegfa)90Ala
Common Name TOPO
Description NPHS2 transgene: The rtTA gene was placed under the control
of the human NPHS2 gene. The resulting transgene is
expressed in the kidney when induced by doxycycline.

tetO transgene: This transgene contains cDNA for the murine
Vegfa isoform VEGF-A164 which was inserted between seven
copies of the tetracycline Operator (tetO)7-CMV minimal
promoter and the bovine growth factor polyadenylation
signals sequence. TetO, when present in cells also carrying
a tetracycline transactivator (tTA) or reverse
transactivator (rtTA) transgene, is inactivated or
activated, respectively, by the administration of
tetracycline or its analogue doxycycline.
Development Status Phenotyping ongoing
Creation Method transgenic
Breeding Type intercross
TypeCount
Investigators 1
Experiments 1


Investigators
NameInstitution
Delma VeronYale University


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