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Strain
B6.Cg-Dusp1tm1.1Ambt Tg(Alb-Cre)21Mgn

Summary Data Summary
Official Name B6.Cg-Dusp1tm1.1Ambt Tg(Alb-Cre)21Mgn
Common Name MKP1 LKO
Description MKP-1flox/flox (Mkp-1fl/fl) mice were bred with mice
expressing the Cre recombinase under the control of an
albumin promoter (Alb-Cre) to obtain Alb-Cre–MKP-1flox/+
mice that were backcrossed to Mkp-1fl/fl mice to generate
mice with liver-specific deletion of MKP-1,
Alb-Cre–MKP-1fl/fl, referred to as MKP-1 liver knockout
(MKP1-LKO) mice.

Dusp1 knockin: An FRT-flanked neomycin resistance cassette
with a 5' loxP site was inserted upstream of exon 2. An
additional loxP site was inserted downstream of exon 3.
Flp-mediated recombination removed the selection cassette
and left exons 2 and 3 floxed.
Development Status Phenotyping ongoing
Creation Method knockout
TypeCount
Genomics - Modifications 1
Genomics - Transgenes 1
Experiments 1
Publications 1


Genomic Information
GeneAllele 1Allele 2Protocol
Dusp1knockoutknockoutNot Specified
EnhancerPromoterGeneCopies
Not SpecifiedAlbCRENot Specified






PublicationAltmetricsSubmitted ByPubMed IDStatus
Hepatic mitogen-activated protein kinase phosphatase 1 selectively regulates glucose metabolism and energy homeostasis.
Lawan A, Zhang L, Gatzke F, Min K, Jurczak MJ, Al-Mutairi M, Richter P, Camporez JP, Couvillon A, Pesta D, Roth Flach RJ, Shulman GI, Bennett AM
Molecular and cellular biology, 2015 (35), 26 - 40
Submitted Externally
25312648
Published

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