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Strain
C57BL/6-Lpltm1Ijg Neurod6tm1(cre)Kan/+

Summary Data Summary
Official Name C57BL/6-Lpltm1Ijg Neurod6tm1(cre)Kan/+
Common Name C57BL/6-Lpltm1Ijg Neurod6tm1(cre)Kan/+
Description A single loxP site was introduced into Lpl intron 1 and a
floxed neo was inserted upstream of exon 1. Transient cre
excised the floxed neo, leaving floxed exon 1. Southern blot
confirmed recombination and Northern blot demonstrated
presence of RNA.

The endogenous Neurod6 locus was disrupted by the insertion
of a cassette containing cre recombinase followed by a
neomycin resistance gene in exon 2. The endogenous promoter
drove expression of cre in the granule cells of the
hippocampus.
Development Status Phenotyping ongoing
Creation Method knockout
Breeding Type intercross
TypeCount
Investigators 1
Genomics - Modifications 2
Experiments 3


Investigators
NameInstitution
Robert EckelUniversity of Colorado at Denver and Health Sciences Center


Genomic Information
GeneAllele 1Allele 2Protocol
Lplknockin (lox)knockin (lox)Not Specified
Neurod6knockin (Cre)wildNot Specified


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