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Strain
B6;129S2-Phf21atm1Tba

Summary Data Summary
Official Name B6;129S2-Phf21atm1Tba
Common Name Phf21a
Description BHC80 is a component of BRAF-HDAC complex (BHC) involved in
transcriptional repression of neuron-specific genes in
non-neuronal cells. However, BHC80 is present in both
neuronal and non-neuronal cells. To explore the
physiological importance of BHC80 in vivo, and the precise
mechanism underlying neuron-specific gene repression by
BHC80, we have produced mutant mice lacking Bhc80. The loss
of Bhc80 resulted in neonatal lethality without sucking
mother's breast milk sufficiently. Although Bhc80-deficient
mice showed no developmental defect in the neuronal and
non-neuronal tissues, Bhc80 is indispensable for the
survival of neonatal pups.
Development Status Characterizing multiple lines
Creation Method chemical induced
TypeCount
Investigators 1
Experiments 3


Investigators
NameInstitution
Shigeki IwaseUniversity of Michigan-Ann Arbor


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