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Strain
STOCK Slc17a6tm1Lowl Tg(Pmch-iCre)

Summary Data Summary
Official Name STOCK Slc17a6tm1Lowl Tg(Pmch-iCre)
Common Name STOCK Slc17a6tm1Lowl Tg(Pmch-iCre)
Description One lab-generated strain with no JAX number: iCre ("improved
Cre") inserted at end of Pmch locus;
Crossed with STOCK Slc17a6tm1Lowl/J
to generate Pmch-iCre(het);VGluT2-floxed/floxed mice.
Pmch-iCre;vGlut2-floxed mice can be used to parse the unique
effects of MCH vs glutamate signaling from MCH neurons as it
pertains to energy balance, glucose sensing, and body
weight.
The Pmch-iCre mouse is a knock-in. These mice were crossed
to the commercially available vGlut2-floxed mice which
resulted in loss of vGluT2 in MCH cells.
Development Status Phenotyping ongoing
Creation Method transgenic
TypeCount
Investigators 1
Genomics - Modifications 1
Genomics - Transgenes 1
Experiments 5


Investigators
NameInstitution
Bethany BeeklyUniversity of Michigan-Ann Arbor


Genomic Information
GeneAllele 1Allele 2Protocol
Slc17a6knockinknockinNot Specified
EnhancerPromoterGeneCopies
Not SpecifiedPmchCRENot Specified


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