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Experiment

Metabolic measurements in ApoE KO mice treated with metformin and niclosamide
pt2
Summary Data Summary
Investigator Shengkan, Jin
Description In this study we used the apoE deficient mice (C57BL6/J background, from the
Jackson laboratory). In the study, we have two groups of mice, each group
contains 7 mice. One group was fed with the standard mouse chow (AIN-93M from
the Research Diets, Inc.) as control; the other group was fed with the same diet
but supplemented 2000 p.p.m. niclosamide ethanolamine. The treatment started
from 6 week age of the mice and continued for 10 weeks. The plasma samples were
collected after 4, 6 and 8 weeks of treatment. For the Week 4 and Week 6 samples
were collected after 16 hours fasting, and for Week 8 samples were collected
after 5 hours fasting.

Applicable research area(s): Metabolism
Status Completed
Public Release 6/14/2018
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame Strain
Data Analysis
TypeCount
Animals45
Experimental Conditions8
Catalog Items8
Curation Info (# flags)1
Phenotype Assays8
Phenotype Measurements360
Histology Images0
Publications0


Animals

Strain NameCommon NameFemalesMalesUnknown
Apoe-/-
0
45
0


Experimental Factors
 Name / AbbreviationDescription

Experimental Factor: Drug Administered

 Metformin
Metformin is a drug approved by the U.S. Food and Drug Administration as a prescription medication to treat diabetes. This medication is used to decrease hepatic (liver) glucose production, to decrease GI glucose absorption and to increase target...
 Vehicle
Vehicle - Control

Experimental Factor: Drug Dose Units

 mg/kg/d
milligrams per kilograms per day

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Feeding Group

 Fasted
Animals are deprived of food but not water.

Experimental Factor: Mouse Diet

 Research Diets - D10012M
Research Diets - AIN-93M Rodent Diet with 9.4% fat, 75.9% carbohydrate, 14.7% protein
 Research Diets - D10012M 2000 ppm NEN
Research Diets - AIN-93M Rodent Diet with 9.4% fat, 75.9% carbohydrate, 14.7% protein supplemented with 2000 ppm niclosamide ethanolamine (NEN)
 Research Diets - D10012M 2000 ppm NEN & 2% COL
Research Diets - AIN-93M Rodent Diet with 9.4% fat, 75.9% carbohydrate, 14.7% protein supplemented with 2000 ppm niclosamide ethanolamine (NLM) 2% colestyramine (COL)

Experimental Factor: Tissue Source

 plasma (lithium heparin)
plasma (lithium heparin)



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