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Experiment

Metabolic measurements in ApoE KO mice treated with metformin and niclosamide
pt2
Summary Data Summary
Investigator Shengkan, Jin
Description In this study we used the apoE deficient mice (C57BL6/J background, from the
Jackson laboratory). In the study, we have two groups of mice, each group
contains 7 mice. One group was fed with the standard mouse chow (AIN-93M from
the Research Diets, Inc.) as control; the other group was fed with the same diet
but supplemented 2000 p.p.m. niclosamide ethanolamine. The treatment started
from 6 week age of the mice and continued for 10 weeks. The plasma samples were
collected after 4, 6 and 8 weeks of treatment. For the Week 4 and Week 6 samples
were collected after 16 hours fasting, and for Week 8 samples were collected
after 5 hours fasting.

Applicable research area(s): Metabolism
Status Completed
Public Release 6/14/2018
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame Strain
Data Analysis
TypeCount
Animals45
Experimental Conditions8
Catalog Items8
Curation Info (# flags)1
Phenotype Assays8
Phenotype Measurements360
Histology Images0
Publications0


Animals

Strain NameCommon NameFemalesMalesUnknown
Apoe-/-
0
45
0


Experimental Conditions
NameUnits
Drug Administeredone of [1GHI, 2-Fucosyllactose, ...]
Drug Dosearbitrary units (AU)
Drug Dose Unitsone of [%, µg once, ...]
Experimental Groupone of [Control, Control-Het, ...]
Fast Durationhour (hr)
Feeding Groupone of [Fasted, Fed, ...]
Mouse Dietone of [3mAIN76(HF0.18), 3mAIN76(HF0.18)early, ...]
Tissue Sourceone of [16-cell embryo, 2-cell embryo, ...]



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