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New comment to be added:
Metabolic measurements in ApoE KO mice treated with metformin and niclosamide
In this study we used the apoE deficient mice (C57BL6/J background, from the
Jackson laboratory). In the study, we have two groups of mice, each group
contains 7 mice. One group was fed with the standard mouse chow (AIN-93M from
the Research Diets, Inc.) as control; the other group was fed with the same diet
but supplemented 2000 p.p.m. niclosamide ethanolamine. The treatment started
from 6 week age of the mice and continued for 10 weeks. The plasma samples were
collected after 4, 6 and 8 weeks of treatment. For the Week 4 and Week 6 samples
were collected after 16 hours fasting, and for Week 8 samples were collected
after 5 hours fasting.
Applicable research area(s): Metabolism
week(s) post-natal (w)
DOWNLOAD ALL DATA (.csv)
Curation Info (# flags)
one of [1GHI, 2-Fucosyllactose, ...]
arbitrary units (AU)
Drug Dose Units
one of [%, µg once, ...]
one of [Control, Control-Het, ...]
one of [Fasted, Fed, ...]
one of [3mAIN76(HF0.18), 3mAIN76(HF0.18)early, ...]
one of [16-cell embryo, 2-cell embryo, ...]
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non-esterified free fatty acids
cholesterol, HDL, plasma
cholesterol, LDL and VLDL
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Financial support for this work was provided by the NIDDK Mouse Metabolic Phenotyping Centers (National MMPC, RRID:SCR_008997,
) under the MICROMouse Program, grants DK076169.
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