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Experiment

Analytical Study in Transgenic Mice with Mutation in Survival Motor Neuron Gene
Summary Data Summary
Investigator Kothary, Rashmi
Description Provide model of spinal muscular atrophy.

Applicable research area(s): Meatbolism, Neurobiology
Status Completed
Public Release 11/1/2019
Animal Age Measured In: week(s) post-natal (w)
Data Analysis
TypeCount
Animals20
Experimental Conditions1
Catalog Items11
Curation Info (# flags)0
Phenotype Assays12
Phenotype Measurements240
Histology Images0
Publications0
Phenotypes11


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6
0
10
0
Smn1tm1Msd/tm1Rako
0
10
0


Experimental Factors
 Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.



No documents found.


Mammalian Phenotype (MP) Terms

MPTermIDMPTermNameDefinitionOther Results
MP:0000182increased circulating LDL cholesterol level
greater amount in the blood of the lipoprotein:cholesterol complex that transports cholesterol out of the arteries and around the body| for use by various tissues in normal bodily functions [MGI:csmith]
MMPC Search Results
MP:0000186decreased circulating HDL cholesterol level
reduced amount in the blood of the small lipoprotein:cholesterol complex that transports cholesterol out of the arteries and to the liver for reprocessing or excretion [MGI:csmith]
MMPC Search Results
MP:0001552increased circulating triglyceride level
greater concentration of naturally occurring esters of three fatty acids and glycerol in the blood; triglycerides are widespread in adipose tissue| commonly circulate in the blood in the form of lipoproteins| and are involved in the process of bidirectional transference of adipose fat and blood glucose with the liver [MGI:csmith]
MMPC Search Results
MP:0001554increased circulating free fatty acid level
higher than normal levels of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacyglycerols are taken into tissues [ISBN:0-683-40008-8]
MMPC Search Results
MP:0002941increased circulating alanine transaminase level
increased concentration in the blood of the enzyme which transfers amino groups from l-alanine to 2 ketoglutarate| or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction [ISBN:0-683-40008-8| MGI:pvb]
MMPC Search Results
MP:0002963decreased urine protein level
less than the normal amount of proteins in the urine [MGI:csmith| RGD:cur]
MMPC Search Results
MP:0005178increased circulating cholesterol level
greater than the normal amount in the blood of the principal sterol of vertebrates and the precursor of many steroids| including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues [MGI:csmith]
MMPC Search Results
MP:0005343increased circulating aspartate transaminase level
greater than normal concentration in the blood of this enzyme| which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid| forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction [ISBN:0-683-40008-8| MGI:pvb]
MMPC Search Results
MP:0005344increased circulating bilirubin level
increased concentration in the blood of the bile pigment bilirubin| normally found in the liver and in red blood cells [ISBN:0-683-40008-8| MGI:csmith]
MMPC Search Results
MP:0005419decreased circulating serum albumin level
blood serum albumin concentration below the normal range [MGI:csmith]
MMPC Search Results
MP:0005567decreased circulating total protein level
total serum protein level below the normal range [RGD:cur]
MMPC Search Results

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