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Effect of Tbr2 mutation on voluntary running (circadian rhythm) in response to a
standard (6:00/18:00) vs jet lag (9:00/21:00) light cycle.
Summary Data Summary
Investigator Feldheim, David
Description Previous studies indicate that T-box transcription factor Tbr2 is required for
the development of several retinal ganglion cell (RGC) types that participate in
non-image-forming circuits. This includes intrinsically photosensitive RGC
(ipRGC) that are known to be involved in behaviors such as day/night activity
cycles. However,there is little information on how disruption of Tbr2 in an
adult animal alters the circadian response to various light/dark cycles. The
purpose of this study is to determine how TBR2 cond KO voluntary running
activity response to alteration of light-dark cycle’s compares to control mice.

TBR2 was conditionally knocked out at 1 month of age by IP tamoxifen injection
(experimental group), controls were injected with saline. All mice had running
activity assessed at standard light dark cycle (600:1800, Circadian rhythm was
not disrupted) and jet lag (900:2100, Circadian rhythm disrupted).
Status Completed
Public Release 2/22/2021
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame Strain
Data Analysis
Experimental Conditions4
Catalog Items3
Curation Info (# flags)1
Phenotype Assays3
Phenotype Measurements672
Histology Images0

Strain NameCommon NameFemalesMalesUnknown
Tbr2 cond/cond

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Circadian Disruption

Circadian rhythm was disrupted.
 Not Disrupted
Circadian rhythm was not disrupted.

Experimental Factor: Experimental Group

This animal belongs to the control group for the experiment.
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Light-Dark Period

The Dark period
The light period

Experimental Factor: Wheel Running (day)

 Wheel Running
The numerical day on which the wheel running measurement was collected.

Phenotype Assays Add / Edit

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