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Experiment

Liver TG levels in Lep KO mice treated with anitbiotics
Summary Data Summary
Investigator Knotts, Trina
Description Deletion of leptin in the Ob/Ob mouse (B6.Cg-Lep/J) produces a deleterious
metabolic phenotype. Mice are obese with many of the deleterious effects of
obesity (hyperphagia, transient hyperglycemia, glucose intolerance, elevated
plasma insulin, hypometabolic, and hypothermic) independent of a high fat,
high-energy diet.
Status Completed
Public Release 1/10/2021
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame Strain
Data Analysis
TypeCount
Animals49
Experimental Conditions7
Catalog Items4
Curation Info (# flags)1
Phenotype Assays2
Phenotype Measurements98
Histology Images0
Publications0


Animals
Strain NameCommon NameFemalesMalesUnknown
C57BL/6J
0
24
0
ob/ob
0
25
0

Animals/Strains
Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Drug Administered

 Cefaperazone
Semisynthetic broad-spectrum cephalosporin with a tetrazolyl moiety that is resistant to beta-lactamase. It has been proposed especially against Pseudomonas infections.
 Vancomycin, Neomycin
0.5 g/L Vancomycin and 1.0 g/L Neomycin combination
 Vehicle
Vehicle - Control

Experimental Factor: Drug Delivery Route

 Drinking Water
The drug was delivered in the drinking water.

Experimental Factor: Drug Dose Units

 g/L
grams per liter

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Mouse Diet

 Research Diets - D12450J
Rodent Diet with 10% fat, 70% carbohydrate, 20% protein

Experimental Factor: Tissue Source

 liver
liver
Experimental Factor Values


Phenotype Assays Add / Edit


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