University of California Davis
University of Cincinnati Medical Center
University of Massachusetts Medical School
University of Michigan Medical School
Vanderbilt University School of Medicine
Protocols & Methods
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Energy Expenditure Analysis
CalR: Indirect Calorimetry Analysis
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Measurement of standard energy expenditure at 22C in Control and RyR1-R163C
Examine effect of Ryr1 mutation on energy expenditure in temperature-challenged
MH is a life-threatening pharmacogenetic syndrome, which occurs when susceptible
individuals are exposed to triggering agents, such as halogenated inhalation
anesthetics and/or depolarizing muscle relaxants. MH susceptibility is
associated with a dysfunction of regulation of intracellular resting Ca2+
concentration ([Ca2+]r) and is characterized by the occurrence of a robust
increase in [Ca2+]r in response to exposure to halothane. In more than 70% of
humans with MH susceptibility (MHS) the trait is linked to one of >185 mutations
within RYR1 located on ch19q13.1, the gene that encodes the type 1 skeletal
isoform of the ryanodine receptor (RYR1), the primary Ca2+ release channel in
the sarcoplasmic reticulum (SR). In addition, mutations in CACNA1S on ch1q31–32,
which codes for CaV1.1 have also been found in 2% of MHS individuals.
Applicable research area(s): Cardiovascular, Metabolism
day(s) post-natal (d)
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Curation Info (# flags)
Name / Abbreviation
Experimental Factor: Experimental Group
This animal belongs to the control group for the experiment.
This animal belongs to the experimental group and is heterozygous wild type/mutation for the affected locus.
Experimental Factor: Mouse Diet
Teklad - 2918
Harlan-Teklad 2918 (Irradiated) 18.6% protein (Calories : 24% protein, 18% Fat, 58% Carbohydrate) Ingredients—Ground wheat, ground corn, wheat middlings, dehulled soybean meal, corn gluten meal, soybean oil, calcium carbonate, brewers dried yeast,...
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energy intake (24 hr)
energy intake (24 hr)
oxygen consumption (Light Period)
fat body mass
fat body mass
lean body mass
lean body mass
respiratory exchange ratio (Light Period)
fat tissue, %
% body fat
heat (Light Period)
oxygen consumption (Dark Period)
carbon dioxide production Light Period
carbon dioxide production Dark Period
respiratory exchange ratio (Dark Period)
heat (Dark Period)
carbon dioxide production
respiratory exchange ratio
energy intake (Light Period)
food intake - light
food intake (Dark Period)
food intake - dark
energy intake (Ligth Period)
energy intake -light
energy intake (Dark Period)
energy intake - dark
Activity 24h (total x-axis)
Activity 24h total x
Activity 24h (x-ambulatory)
Activity 24h (x-amb)
Activity 24h (total vertical z-axis)
Activity 24h total z
total tissue mass
heat - 24h
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