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Experiment

TFAM skms transgenic chow and HFD clamps

Summary

Data Summary

Investigator	Johnson, Matthew
Description	The pathophysiology of Type 2 diabetes has been attributed to insulin resistance, particularly in the liver and muscle. As skeletal muscle is a major site of glucose utilization, its metabolic capacity may influence insulin resistance. Patients at risk for insulin resistance, such as sedentary individuals, have a decreased content of mitochondria in skeletal muscle, and endurance trained athletes have high insulin sensitivity in the presence of high mitochondrial content. The TFAM transgenic mouse model with muscle specific overexpression of Mitochondrial Transcription Factor A (TFAM) are used to study the pathway of mitochondrial biogenesis and its implications for systemic physiology and health.
Status	Completed
Public Release	5/31/2017
Data Collected?	Data will not be collected for this catalog item
Animal Age	Measured In: month(s) post-natal (m)
Flags

Data Analysis

Type	Count
Animals	0
Experimental Conditions	1
Catalog Items	1
Curation Info (# flags)	0
Phenotype Assays	15
Phenotype Measurements	0
Histology Images	0
Publications	0

Animals/Strains

Experimental Factors

Experimental Factor (Units)
Experimental Group

Experimental Factor Values

Phenotype Assays Add / Edit

Name	Abbreviation
glucose uptake	glucose uptake
average clamp glucose	average clamp glucose
glucose infusion rate	glucose infusion rate
fat body mass	fat body mass
lean body mass	lean body mass
total body weight	total body weight
Age	Age
glucose, basal	glucose, basal
hepatic glucose production, basal	hepatic glucose production, basal
glucose synthesis	glucose synthesis
glucose turnover, whole body	glucose turnover, whole body
glycogen/lipid synthesis, whole body	glycogen/lipid synthesis, whole body
glycolysis, whole body	glycolysis, whole body
glycogen synthesis	glycogen synthesis
glycolysis	glycolysis

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