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TFAM skms transgenic chow and HFD clamps
Summary Data Summary
Investigator Johnson, Matthew
Description The pathophysiology of Type 2 diabetes has been attributed to insulin
resistance, particularly in the liver and muscle. As skeletal muscle is a major
site of glucose utilization, its metabolic capacity may influence insulin
resistance. Patients at risk for insulin resistance, such as sedentary
individuals, have a decreased content of mitochondria in skeletal muscle, and
endurance trained athletes have high insulin sensitivity in the presence of high
mitochondrial content. The TFAM transgenic mouse model with muscle specific
overexpression of Mitochondrial Transcription Factor A (TFAM) are used to study
the pathway of mitochondrial biogenesis and its implications for systemic
physiology and health.
Status Completed
Public Release 5/31/2017
Data Collected? Data will not be collected for this catalog item
Animal Age Measured In: month(s) post-natal (m)
Data Analysis
Experimental Conditions1
Catalog Items1
Curation Info (# flags)0
Phenotype Assays15
Phenotype Measurements0
Histology Images0

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Experimental Group

This animal belongs to experimental group that is homozygous for gene manipulations.
This animal belongs to the control group for the experiment.
This animal belongs to the experimental group and is heterozygous wild type/mutation for the affected locus.
This animal belongs to the control group and is heterozygous wild type/mutation for the affected locus.
Experimental Factor (Units)
Experimental Group

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