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Publication
Diabetes in mice with selective impairment of insulin action in Glut4-expressing
tissues.
Authors Lin HV, Ren H, Samuel VT, Lee HY, Lu TY, Shulman GI, Accili D
Submitted By Domenico Accili on 9/18/2012
Status Published
Journal Diabetes
Year 2011
Date Published
Volume : Pages 60 : 700 - 709
PubMed Reference 21266328
Abstract Impaired insulin-dependent glucose disposal in muscle and fat is a harbinger of
type 2 diabetes, but murine models of selective insulin resistance at these two
sites are conspicuous by their failure to cause hyperglycemia. A defining
feature of muscle and fat vis-à-vis insulin signaling is that they both express
the insulin-sensitive glucose transporter Glut4. We hypothesized that diabetes
is the result of impaired insulin signaling in all Glut4-expressing tissues.




Strains
StrainDevelopment StatusCreation MethodOptions
STOCK Insrtm1KhnPhenotyping ongoingknockin
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STOCK Insrtm1Khn Tg(Slc2a4-cre)Phenotyping ongoingknockout
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