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Strain
STOCK Insrtm1Khn Tg(Slc2a4-cre)

Summary Data Summary
Official Name STOCK Insrtm1Khn Tg(Slc2a4-cre)
Common Name GIRKO
Description C57BL/6J with floxed Insulin receptor gene and transgene
carrying the CRE gene driven by the Glut4 promoter

Glut4-cre transgenics were intercrossed with Insrflox/flox
mice, and the resulting progeny was intercrossed to yield
Insrflox/flox controls and Insrflox/flox, GLUT4-cre (GIRKO)
mice that were used for all subsequent phenotypic analyses.
Animals were maintained on a mixed background derived from
129/Sv, C57BL/6, and FVB.
Development Status Phenotyping ongoing
Creation Method knockout
Background C57BL/6J
Breeding Type intercross
TypeCount
Investigators 1
Genomics - Modifications 1
Genomics - Transgenes 1
Experiments 1
Publications 1


Investigators
NameInstitution
Domenico AcciliColumbia University


Genomic Information
GeneAllele 1Allele 2Protocol
Insrknockin (lox)knockin (lox)Not Specified
EnhancerPromoterGeneCopies
Not SpecifiedSlc2a4CRENot Specified






PublicationAltmetricsSubmitted ByPubMed IDStatus
Diabetes in mice with selective impairment of insulin action in Glut4-expressing tissues.
Lin HV, Ren H, Samuel VT, Lee HY, Lu TY, Shulman GI, Accili D
Diabetes, 2011 (60), 700 - 709
21266328
Published

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