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Strain
STOCK Insrtm1Khn

Summary Data Summary
Official Name STOCK Insrtm1Khn
Common Name C57BL/6-Insrflox/flox
Description Exon 4 was left flanked by single loxP sites after a
downstream floxed neo cassette was removed via in vitro cre
mediated recombination. Deletion of the resultant floxed
fragment will result in a frameshift mutation that
introduces a stop codon. Translation, if it were to occur,
would putatively produce a truncated peptide consisting of
308 amino terminal residues and lacking the high affinity
binding site, transmembrane domain, and kinase domain.

Animals maintained on mixed background consisting of
C57BL/6, 129/Sv, and FVB/N
Development Status Phenotyping ongoing
Creation Method knockin
Background C57BL/6J
Breeding Type intercross
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 1
Publications 1


Investigators
NameInstitution
Domenico AcciliColumbia University


Genomic Information
GeneAllele 1Allele 2Protocol
Insrknockin (lox)knockin (lox)Not Specified






PublicationAltmetricsSubmitted ByPubMed IDStatus
Diabetes in mice with selective impairment of insulin action in Glut4-expressing tissues.
Lin HV, Ren H, Samuel VT, Lee HY, Lu TY, Shulman GI, Accili D
Diabetes, 2011 (60), 700 - 709
21266328
Published

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