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Strain
C57BL/6-Npc1l1tm1Yaio

Summary Data Summary
Official Name C57BL/6-Npc1l1tm1Yaio
Common Name L1 KO
Description The insertion of a PGK-neo cassette into exon 2 at
nucleotide 91263 interrupted the gene after cDNA nucleotide
601, thereby abrogating any alternatively spliced gene
forms.
Development Status Phenotyping ongoing
Creation Method knockout
Background C57BL/6J
Phenotype Description Mice homozygous for a targeted null mutation in Npc1l1
exhibit normal intestinal development, fertility and plasma
cholesterol and triglyceride levels; however, intestinal
cholesterol absorption was substantially reduced.
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 1
Publications 1


Investigators
NameInstitution
Liqing YuWake Forest University Baptist Medical Center


Genomic Information
GeneAllele 1Allele 2Protocol
Npc1l1knockoutknockoutNot Specified






PublicationAltmetricsSubmitted ByPubMed IDStatus
Submitted Externally
20601625
Published

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