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Strain
C57BL/6J-Tg(Acta2-Cyba)

Summary Data Summary
Official Name C57BL/6J-Tg(Acta2-Cyba)
Common Name C57BL/6J-Tg(SMP-8-p22phox)
Description p22phox was cloned downstream of the smooth muscle a-actin
promoter fragment SMP-8 and upstream of a SV40 poly A
fragment. These mice over express p22phox in vascular smooth
muscle and have increased vascular ROS production.
Development Status Phenotyping ongoing
Creation Method transgenic
Background C57BL/6J
Breeding Type intercross
Phenotype Description p22phox was cloned downstream of the smooth muscle a-actin
promoter fragment SMP-8 and upstream of a SV40 poly A
fragment. These mice over express p22phox in vascular smooth
muscle and have increased vascular ROS production.
TypeCount
Investigators 1
Genomics - Transgenes 1
Experiments 1


Investigators
NameInstitution
David HarrisonVanderbilt University


Genomic Information
EnhancerPromoterGeneCopies
Not SpecifiedActa2CybaNot Specified


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