mmpc-logo mmpc-logo
twitter-logo    bluesky-logo
| Create Account | login
Strain
C57BL/6-Tg(Csf1r-EGFP-NGFR/FKBP1A/TNFRSF6)2Bck Ldlrtm1Her

Summary Data Summary
Official Name C57BL/6-Tg(Csf1r-EGFP-NGFR/FKBP1A/TNFRSF6)2Bck Ldlrtm1Her
Common Name C57BL/6-Tg(Csf1r-EGFP-NGFR/FKBP1A/TNFRSF6)2Bck Ldlrtm1Her
Description Mice homozygous for the Ldlr tm1Her mutation have an
elevated serum cholesterol level of 200-400 mg/dl and they
have very high levels (>2,000 mg/dl) when fed a high fat
diet. Normal serum cholesterol in the mouse is 80-100 mg/dl.

These macrophage Fas-Induced apoptosis transgenic mice allow
inducible/reversible apoptosis of macrophages and dendritic
cells using the mouse colony stimulating factor 1 receptor
promoter (Csf1r) to drive expression of a mutant human FK506
binding protein 1A, 12kDa. The transgene also allows
fluorescent labeling of Csf1r-expressing cells. These mice
may be useful in investigating the role of macrophages and
dendritic cells.
Development Status Phenotyping ongoing
Maternal Strain C57BL/6-Tg(Csf1r-EGFP-NGFR/FKBP1A/TNFRSF6)2Bck/J
Paternal Strain B6.129S7-Ldlrtm1Her/J
Background C57BL/6
Breeding Type intercross
TypeCount
Investigators 1
Genomics - Modifications 1
Genomics - Transgenes 3


Investigators
NameInstitution
Willa HsuehOhio State University-Main Campus


Genomic Information
GeneAllele 1Allele 2Protocol
LdlrknockoutknockoutNot Specified
EnhancerPromoterGeneCopies
Not SpecifiedCsf1rNgfrNot Specified
Not SpecifiedCsf1rFkbp1aNot Specified
Not SpecifiedCsf1rTnfrsf6Not Specified

Menu

Home
Contact
About MMPC
Animal Husbandry
Tests Data
Search Data
Analysis
Clients
MMPC Centers

Newsletter

Interested in receiving MMPC News?
twitter-logo Mouse Phenotyping
@NationalMMPC



2017 National MMPC. All Rights Reserved.