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Strain
129S6/SvEvTac-Bco2tm1Dnp

Summary Data Summary
Official Name 129S6/SvEvTac-Bco2tm1Dnp
Common Name 129S6/SvEvTac-Bco2-/-
Description Global knockout of beta-carotene oxygenase 2 (Bco2). A lacZ
and neo cassette replaced exons 1 through 4 and part of exon
5.
Development Status Phenotyping ongoing
Creation Method knockout
Background 129S6/SvEvTac
Phenotype Description Mice homozygous for a knock-out allele exhibit increased
spleen weight, decreased testis and seminal vesicle weight,
and increased tissue lycopene and beta-carotene levels when
fed diets containing tomato powder or lycopene. This strain
develops more obese phenotype compared with the genetic
background 129S6 when fed a high fat diet. Those mice show
altered mitochondrial activities.
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 1
Publications 1


Investigators
NameInstitution
Dingbo LinOklahoma State University


Genomic Information
GeneAllele 1Allele 2Protocol
Bco2knockoutknockoutNot Specified






PublicationAltmetricsSubmitted ByPubMed IDStatus
Genetic dissection in a mouse model reveals interactions between carotenoids and lipid metabolism.
Palczewski G, Widjaja-Adhi MA, Amengual J, Golczak M, von Lintig J
Journal of lipid research, 2016 (57), 1684 - 95
Submitted Externally
27389691
Published

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