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Strain
B6.129S4-Mc4rtm1Dhu

Summary Data Summary
Official Name B6.129S4-Mc4rtm1Dhu
Common Name Mc4r-/-
Description A neomycin selection cassette replaced all but the first 20
nucleotides of the coding region of Mc4r. Northern blot
analysis showed a lack of transcript in homozygous mice.
Development Status Phenotyping ongoing
Creation Method knockout
Phenotype Description The animals are an obese phenotype with hyperphagia and
suspected issues with
energy expenditure.
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 2
Publications 1


Investigators
NameInstitution
Richard SimerlyVanderbilt University


Genomic Information
GeneAllele 1Allele 2Protocol
Mc4rknockoutknockoutNot Specified






PublicationAltmetricsSubmitted ByPubMed IDStatus
Loss of the melanocortin-4 receptor in mice causes dilated cardiomyopathy.
Litt MJ, Okoye GD, Lark D, Cakir I, Moore C, Barber MC, Atkinson J, Fessel J, Moslehi J, Cone RD
eLife, 2017 (6)
Submitted Externally
28829041
Published

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