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Strain
C57BL/6NCrl-Mbem2Shad/Mbp

Summary Data Summary
Official Name C57BL/6NCrl-Mbem2Shad/Mbp
Common Name MbKA
Description double SNP mutant (K46A and K64A)

This mutation limits Mb (myoglobin) binding through two
K-to-A mutations in the binding pocket

When fed a high-fat diet, Mb-KA mutant mice displayed
increased body fat and weight gain, despite no clear
differences in whole-body fat oxidation or energy intake,
compared to wild-type mice. Males also have reduced insulin
sensitivity.
Development Status Phenotyping ongoing
Creation Method knockout
Breeding Type intercross
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 4


Investigators
NameInstitution
Sean AdamsUniversity of California Davis


Genomic Information
GeneAllele 1Allele 2Protocol
MbknockoutknockoutNot Specified


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