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double SNP mutant (K46A and K64A)
This mutation limits Mb (myoglobin) binding through two
K-to-A mutations in the binding pocket
When fed a high-fat diet, Mb-KA mutant mice displayed
increased body fat and weight gain, despite no clear
differences in whole-body fat oxidation or energy intake,
compared to wild-type mice. Males also have reduced insulin
Genomics - Modifications
University of California Davis
Curation Flag Information
New comment to be added:
Influence of Myo K64A mutation on glucose tolerance
Influence of Myo K64A mutation on glucose tolerance and insulin stimulate AKT signaling
Influence of Myo K64A mutation on insulin tolerance
Influence of Myo K64A mutation on metabolic phenotype and energy balance
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Financial support for this work was provided by the NIDDK Mouse Metabolic Phenotyping Centers (National MMPC, RRID:SCR_008997,
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