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Strain

B6.129S6-Myc^tm2Fwa/Mmjax

Summary

Data Summary

Official Name	B6.129S6-Myc^tm2Fwa/Mmjax
Common Name	B6.129S6-Myc^tm2Fwa/Mmjax
Description	This targeted mutation of the myelocytomatosis oncogene (Myc) gene may be useful in generating conditional mutations to study B cell activation and proliferation, neural crest cell development, and mouse embryonic fibroblast proliferation. A single loxP site was inserted into intron 1 and a loxP-flanked neomycin selection cassette was inserted 3' to exon 3. The neomycin cassette was removed in ES cells by transient Cre expression prior to the production of chimeric mice.
Development Status	Not specified/Other
Creation Method	congenic

Type	Count
Genomics - Modifications	1
Experiments	10

Genomic Information

Gene	Allele 1	Allele 2	Protocol
Myc	knockin (lox)	knockin (lox)	Not Specified

OrderID	Order	Investigator	Experiment	Status	Measurements
30450	30450	Claudia Rodrigues	Circulating ALT, AST levels in Myc KO mice fed high fat and high cholesterol diet	Completed	74
30450	30450	Claudia Rodrigues	Circulating lipid levels levels in Myc KO mice fed chow diet	Completed	192
30669	30669	Claudia Rodrigues	Circulating lipid levels levels in Myc KO mice fed high cholesterol diet	Completed	111
30450	30450	Claudia Rodrigues	Circulating lipid levels levels in Myc KO mice fed high fat and high cholesterol diet	Completed	81
30450	30450	Claudia Rodrigues	Circulating lipid levels levels in Myc KO mice fed high fat and high cholesterol diet Pt2	Completed	231
30450	30450	Claudia Rodrigues	Liver lipid levels in Myc KO mice fed chow diet	Completed	56
30378	30378	Claudia Rodrigues	Liver lipid levels in Myc KO mice fed high fat and high cholesterol diet	Completed	70
30450	30450	Claudia Rodrigues	Liver lipid levels in Myc KO mice fed high fat and high cholesterol diet Pt 2	Completed	38
30450	30450	Claudia Rodrigues	Liver lipid levels in Myc KO mice fed high fat and high cholesterol diet Pt 3	Completed	150
30669	30669	Claudia Rodrigues	Liver lipid levels levels in Myc KO mice fed high cholesterol diet	Completed	74

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