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Experiment

Influence of miR-148a on hepatic lipid metabolism
Summary Data Summary
Investigator Goedeke, Leigh
Description The ApoBTg; LDLR+/- mice express high levels of human apolipoprotein B100 and
show elevated serum levels of LDL cholesterol. In addition, when
fed a high fat diet, they develop complex atherosclerotic lesions. As such they
are useful for identifying and evaluating compounds to reduce elevated levels of
LDL cholesterol and the risk of atherosclerosis.

These mice were used to test the therapeutic potential of inhibiting miR-148a
expression to reduce levels of circulating LDL-C and increase levels of plasma
HDL-C. Preliminary results show that inhibiting miR-148a expression alters
plasma cholesterol in mice.
Status Completed
Public Release 11/12/2017
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame Strain
Data Analysis
TypeCount
Animals20
Experimental Conditions1
Catalog Items4
Curation Info (# flags)1
Phenotype Assays4
Phenotype Measurements79
Histology Images0
Publications0


Animals
Strain NameCommon NameFemalesMalesUnknown
C57BL/6
6
3
0
B6.129S7-Ldlrtm1Her Tg(APOB)1102Sgy
7
4
0

Animals/Strains
Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.
Experimental Factor (Units)
Experimental Group
Experimental Factor Values


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