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Circulating lipid, insulin, ALT and AST levels in Lepr KO mice treated with
derivatives of niclosamide
Summary Data Summary
Investigator Shengkan, Jin
Description BKS.Cg-Dock7m +/+ Leprdb/J mice received daily oral gavage of vehicle or
1.25mg/kg or 2.5mg/kg or 5.0mg/kg body weight of Y03 for 4 weeks. Non-fast, 5
hour-fasted and over night fasted blood was collected through tail vein bleeding
at the end of the treatment. Plasma was obtained by centrifugation at 1000g for
10-15min at 4? . Whole blood and plasma stored at -80? for further analysis. Y03
are from a group of mitochondrial uncouplers that can stimulates oxygen
consumption. Hypothesis: oral administration of mitochondrial uncouplers could
reduce blood glucose level and improve insulin resistance. The objective of the
study is to investigate the effect of mitochondrial uncouplers on the treatment
of type 2 diabetes.

Applicable research areas: Diabetes, Endocrine deficiency, and Metabolism
Status Completed
Public Release 3/26/2022
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame StrainAnimal Count
Data Analysis
Experimental Conditions9
Catalog Items8
Curation Info (# flags)2
Phenotype Assays8
Phenotype Measurements384
Histology Images0

Strain NameCommon NameFemalesMalesUnknown
BKS db

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Drug Administered

Vehicle - Control
Y03, a niclosamide derivative, in 2% DMSO, 10% solutol, 88% of 20% beta-cyclodextrin solution.

Experimental Factor: Drug Delivery Route

The drug was delivered orally

Experimental Factor: Drug Dose Units

milligrams per kilograms per day

Experimental Factor: Experimental Group

This animal belongs to the control group for the experiment.
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Feeding Group

Animals are deprived of food but not water.
Animals are allowed to have food.

Experimental Factor: Mouse Diet

 Research Diets - D16012006
Research Diets - AIN-93M Rodent Diet with 9.4% fat, 75.9% carbohydrate, 14.7% protein supplemented with 2000 ppm niclosamide ethanolamine (NEN)

Experimental Factor: Tissue Source

 plasma (EDTA)
plasma (EDTA)
Experimental Factor Values

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